Measurement, evaluation and therapeutic measures by means of the Heart Rate Variability:
The heart rate variability (Heart Rate Variability = HRV) is the gold standard amongst cardiologists in the USA. The importance of the heart rate variability in the USA also appears in the fact that about 90% of all publications come from the USA.
In Europe, important research has been done by the Russian scientist, Prof. Bajevsky and the Czech internist Dr. Michael Kucera; Medprevent ltd is going to publish some elaborations in the next months about it.
1. Basics about the heart rate variability (HRV):
The HRV is a measurand of neurovegetative activity and autonomous function of the heart. It describes the ability of the heart to alter the time interval between two consecutive heartbeats (RR-interval) to adapt to internal and external strain of the heart. This adaptability of the heart is based on an optimal interaction of the sympathetic and parasympathetic nervous system.
High-frequency electrical impulses of the parasympathicus result in a rapid decrease of the heart
frequency; the release of acetylcholine leads to vascular dilatation.
Low-frequency impulses of the sympathicus, on the other hand, cause an increase of the heart frequency by releasing adrenaline and noradrenaline.
With increasing physical activity the influence of the parasymphaticus decreases; the sympathicus increases correspondingly with physical activity. Thus the heart rate variability is always larger at rest than during physical activity.
The body achieves a good heart rate variability if sympathicus and parasympathicus (sympathicus = the accelerator pedal of the car is used and the parasympathicus = the brake is technically well maintained and is made reasonable use of) are balanced. By means of the measurements and the evaluations of the heart rate variability by the system ”Varicor“, the interaction between sympathicus and parasympathicus becomes clear:
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2. Measurement of the heart rate variability with Varicor:
The hardware includes the chest belt = transmitter for the acquisition of the determined heart frequency and the receiver module. The collection and evaluation of heartbeats and the transmission of data occurs digitally; the intervals between the single heartbeats (RR-interval) and their fluctuation for heart rates respectively is less than 120 bpm on the on the receiver side with a resolution of at least 1 ms.
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3. Evaluation of the heart rate variability by means of the graphics of ”Varicor“:
Two graphics show the evaluation of a patient with adaptable heart rate Variability and of a patient with strongly reduced heart rate adaptability to strain. The measuring takes 5 minutes, the patient sits down or lies calmly and in a relaxed position during the measuring.
Rythmogram, scatterplot and histogram each show the presetting for a positive result = color green. In the graphic “Main parameter of the heart rythm“, the fourth and fifth bar (stress index = sympathicus and RMSSD = parasympathicus) show if both are balanced.
Here it is decisive if the value SDNN reaches the normal value = 30 - 100. If the SDNN value is positive the patient`s body has enough power to regenerate. A value below 30 or even in the red range = below 10 units means that something has to be done therapeutically. In the computer program you can click each individual bar to receive appropriate information (compare point 5).
The CV value shows the variability of the heart rate; the smaller the CV value the straighter and without any variation is the rythmogram (1700 years ago the Chinese physician Wang Shuhe wrote: “If the heartbeat gets as regular as the knocking of the woodpecker or the dripping of the rain on the roof the patient will die within 4 days“).
A healthy newborn child has a favorable heart rate variability in the ”green“ range. With increasing age it declines more and more, until the CV value - if no prophylaxis or therapy will be done - approaches zero.
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4. Therapeutic measures:
Depending on the patient`s age and the severity of the patient`s result the computer calculates a dispension on the basis of the mitochondrial medicine. Two different dispensions are determined for the patient; we recommend to test the optimal despension for the patient via PROGNOS.
The main components of the dispension is a composition of high-dosed, orthomolecular products that are matched to each other: Coenzyme Q10, hochdosiert; Carnosine; L-Carnitine; Omega 3 fatty acid etc. The energy in the cells is strengthened, free radicals are fought and the emotional brain is strengthened with Omega 3 and Lecithin. When taking the dispension, other additional vitamins, minerals and enzymes should not be taken or only after consulting a physician. Too many or non-matching substances can cause the opposite, i.e. they can also act as radicals then.
In the software of Varicor, 5 different priority levels concerning the dispension for the therapy are programmed. From PR-1.1 (= preventive, no big health problems) to TR-5.1 (= therapy, big health problems) it is printed for each patient individually in the graphic (PR - 1.1 = under 40 years; 1.2 = over 40 years).
The Varicor dispension is contraindicated in patients with hyperthyroidism; in these cases the physician has to decide how the treatment should be continued.
The 20 different Varicor dispensions are ordered via Medprevent (compare enclosed order form); afterwards we forward them to the Kloesterl drug store. The complete handling (shipping and payment) occurs directly via the Kloesterl drug store (handling analog Centropa).
By means of the Varicor - dispension the homeostasis (dynamic balance of the physiological bodily functions) is strengthened, i.e. the autonomous nervous system is normalized. This is reflected in the heart rate variability by an improvement of the SDNN value and a balance of both the sympathicus and parasympathicus.
From the cellular point of view, two processes are typical for aging:
- the cellular energy in the mitochondria is reduced by free radicals due to the destruction of the mitochondria.
- With increasing age the coenzyme Q10 which is produced in the liver is getting less so that this energy giver constantly decreases in the mitochondria.
The supply with Q10 and elimination of the free radicals by antioxidants improves the energy balance in the mitochondria. For this reason, the Varicor dispension is composed of very high-dosed, absolutely pure Q10 and with a multitude of antioxidants.
Furthermore, the Varicor dispension prevents protein structures from being destroyed by means of Carnosine. Here, insulin plays an important role because it opens the cell so that glucose can penetrate.This stimulates the production of insulin, which makes the Varicor dispension a therapy for type 2 as well as type 1 Diabetes Mellitus.
The same applies for an adjuvant Parkinson’s and Alzheimer’s disease.
The improvement of the protein structure, the optimization of energy in the mitochondria, the stimulation of the production of insulin and the increased production of NADH due to citric acid (citric acid cycle) with the formation of ATP cause an even balance of the autonomous nervous system. This can clearly be presented on a graph when measuring with Varicor. If measurements are taken after a regular intake of the Varicor dispension the graphic “comparison” shows the success of therapy.
It is decisive for the optimization of the the homoeostasis that the SDNN value goes back to normal with Varicor. A good SDNN value means that the vegetative nervous system is able to regenerate sufficiently to keep the sympathicus (stress index = SI) and parasympathicus (RMSSD) balanced.
Even if the the stress index (sympathicus) is completely out of joint due to our hectic time, the autonomous nervous system has to/will strengthen the RMSSD value (parasympathicus) in the resting phase again and thus normalize the sympathicus (= homeostasis).
With the Varicor graphics and the individual “grading” of the Varicor dispensions the patient realizes an improvement of his autonomous nervous system with the help of the therapy immediately
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5. The main parameter of the heart rhythm:
5.1. HR
pulse frequency (norm 55 - 80 /min).
values below 55: bradycardia (too low)
values over 80: tachycardia (too high)
5.2. SDNN
Summarizing parameter on the heart rate variability: (standard deviation: 30 - 100) Whether this parameter is rising or falling depends on both autonomous and main regulations (sympathicus and parasympathicus). A rising SDNN shows the increase of activity of the parasympathetic regulation. I.e. the increasing influence of respiration on the heart rhythm (like normal when asleep). A falling SDNN means an increase of smpathetic activity of the vegetative nervous system. A marked decrease of the SDNN results in an involvement of higher (major) levels of the autonomous nervous system in the regulative process (virtually all regulative systems are active).
5.3. CV Coefficient of Variation (norm 3 - 12):
- characterizes variability and thus describes the distribution in the histogram
- low values correlate with a higher sympathetic activity
- higher values correlate with a higher parasympathetic activity
5.4. SI The stress index characterizes the activity of the sympathetic regulation mechanism (50 - 150): state of the central level of the regulation. This parameter reflects the increase of sympathetic main levels under mental, emotional and/or physical strain. This is characterized by a larger stability of the heart rhythm, a decline of the fluctuation difference of the RR interval length and an increase of almost the same RR interval length. With a light increase of strain the stress index rises by 200-300 units; with a permanent strain the stress index rises by 400-600 units (patient with a disease with constantly increased activity of the autonomous regulation system). For patients that suffer from angina pectoris and/or a myocardial infarct the SI rises by 1000-1500 units.
5.5 RMSSD Parameter of the activity of the parasympathetic part (20 - 50):
Reflects the activity of the vegetative autonomous system. The increase of this parameter shows a higher activity of the parasympathetic part of the autonomous regulation. The decrease of RMSSD reflects the decrease in activity of the parasympathetic part of the autonomous nervous system (mostly caused by an increase of sympathetic activity).
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6. The heart-brain system:
Figure 3 shows the link between the heart rate variability and the emotional brain (Servan Schreiber „Die neue Medizin der Emotionen“). Research in the USA has shown that a depression more than doubles the risk of a coronary heart disease, of a heart attack or a sudden cardiac death. The heart rate variability as well as depressions are an expression and measure of a limited adaptability to internal and / or external stress. For this reason, a depressive patient`s heart rate variability has to be examined/treated and vice versa.
7. Heart rate variability with metabolic diseases (diabetes mellitus):
Studies in the USA show a significant disturbance of the autonomous nervous system with a disturbed heart rate variability in patients with diabetes. With the help of mitochondrial medicine, the diabetes patients` heart rate variability may be treated and thus the need of insulin may be reduced considerably. It is characteristic for diabetes that the autonomous nervous system loses balance and harmony due to stress factors - psychological stress as well as oxydative stress in the cells, i.e. sympathicus and parasympathicus drift apart (compare graphic: the stress index (SI) = sympathicus is extremely high, the parasympathicus (RMSSD) is low).
With the help of Varicor, precise diagnostic hints can be given with relatively little expenses and especially thanks to mitochondrial medicine quick and therapeutic success can be achieved then.
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8. Other hints and literature:
As mentioned earlier, 90% to 95% of the literature about Heart Rate Variability is in English, i.e. it’s originally from the USA.
In the meantime, HRV is a very important part of medicine in the USA..
For this reason, also the parameters and normal ranges - e.g. the main parameters of the heart
Rythm - come from the USA, but are valid throughout the world by now.
a.) HR: average frequency of heart rate (55 - 80 / min)
b.) SDNN: standard deviation norm to norm (30 - 100)
c.) CV: coefficient of variability (3 - 12) - msec
d.) SI: stress index (80 - 150)
e.) RMSSD: root mean square of standard deviation (20 - 50)
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9. Summary- Heart Rate Variability (HRV)
9.1.
The HRV is professionally being used with great success only in the USA and Canada at the moment.
9.2.
The HRV can best be used for general practitioners, internists, sports physicians, orthopedists, gynecologists etc. The concise prevention check offers help for the decision whether the therapist treats the patient (medical advice from Dr Kucera possible via email) or whether a referral to cardiologists is necessary.
9.3.
By means of the stress index (=sympathicus) the Varicor measurement shows, if the autonomous nervous system is in homeostasis and if the body is (still) able to regulate
9.4.
Due to the results of the Variocor measurement the computer calculates a individual dispension (mitochondrial medicine) for the patient, which directly treats the autonomous nervous System (heart - brain system).
9.5.
Indications: arrythmias, cardiac flutter, myocardial problems, diabetes
especially type 2, general metabolic problems, ischemia, myocardial infarct
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Good HRV Values
Good HRV Values
Bad HRV Values
Bad HRV Values
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